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KMID : 1123920110250030533
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Korean Journal of Oriental Physiology and Pathology
2011 Volume.25 No. 3 p.533 ~ p.539
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Sulfuretin Inhibits Ultraviolet B-induced MMP Expression in Human Dermal Fibroblasts
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So Hong-Seob
Kim Seung-Hoon
Lee Young-Rae
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Abstract
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Sulfuretin is one of the main flavonoids produced by Rhusverniciflua. Sulfuretin has been shown to exhibit many pharmacological activities including anti-oxidant, anti-obesity, anti-inflammatory and anti-mutagenic activities. However, the anti-skin photoaging effects of sulfuretin has not yet been reported. In the present study, we investigated the inhibitory effect of sulfuretin on the expression levels of MMP-1 and -3 in the human dermal fibroblast cells. Western blot analysis and real-time PCR revealed sulfuretin inhibited UVB-induced MMP-1 and -3 expressions in a dose-dependent manner. UVB-induced MAPK/NF-χB/p50 activation and MMP expression were completely blocked by pretreatment of sulfuretin. Taken together, sulfuretin could prevent UVB-induced MMP expressions through inhibition of MAPK/NF-χB/p50 activation.
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KEYWORD
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UVB, MMP, NF-χＢ, HDFs, Sulfuretin
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